| Identifier | HPI074577 |
| Interaction | Tan IIA <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000092,degradation; IT:0000227,bind; IT:0000128,phosphorylation; IT:0000076,inhibition; IT:0000114,activation; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 19591811_7, At the low dose range (0.2-4 microM) of Tan IIA exposure, the DNA structure damage results in the inhibition of RNAPII binding to DNA and the initiation of RNAPII phosphorylation, while higher concentrations of Tan IIA (4-20 microM) cause complete phosphorylation and degradation of RNAPII followed by p53 activation and apoptosis. |