| Identifier | HPI086506 |
| Interaction | caspase-3 <==> p53 |
| Role & State | RS:0000002,activity; |
| Interaction Type | IT:0000271,express; IT:0000372,treatment; IT:0000115,cleavage; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | DM:0000428,microscopy; DM:0000040,electron microscopy; |
| Reference | 17544621_6, HOC1-induced apoptosis in BEC in a dose-dependent fashion increased the activity of caspase-3 and the expression of p53 and p-JNK.
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| Reference | 20207116_4, Viability of cultured hepatocytes was assessed using the MTT assay, whereas apoptosis processes were evaluated by the electron microscopy, detection of DNA laddering, determination of caspase-3 activity, and measuring annexin V, p53 and Bcl-2 protein concentration.
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| Reference | 21468663_4, In this study, we showed that etoposide treatment activated caspase-8 and caspase-3, leading to cleavages of p53, Bid and PARP, which subsequently induced apoptosis.
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