| Identifier | HPI100419 |
| Interaction | mdm2 protein <==> p53 |
| Role & State | RS:0000077,regulator; RS:0000080,suppressor; |
| Interaction Type | IT:0000114,activation; |
| Biological Process | BP:0016446,mutation; BP:0010467,gene expression; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 10718212_1, Tumor suppressor protein p53 is a positive regulator of MDM2 gene expression and the mdm2 protein can bind to p53, preventing the transactivation of p53 responsive genes, thus mimicking TP53 mutation.
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| Reference | 10718212_5, The finding of co-overexpressed mdm2 and p53 proteins in cholangiocarcinomas indicates that they can upregulate the expression of mdm2 protein to a level sufficient for binding and accumulating p53 in a presumably inactive complexed form.
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