| Identifier | HPI102857 |
| Interaction | p21 <==> p53 |
| Role & State | RS:0000077,regulator; RS:0000074,inhibitor; RS:0000080,suppressor; |
| Interaction Type | IT:0000157,depend; IT:0000077,regulate; IT:0000089,addition; IT:0000287,activate; IT:0000032,increase; IT:0000176,suppress; IT:0000271,express; IT:0000068,transcription; IT:0000316,induce; IT:0000114,activation; IT:0000078,regulation; |
| Biological Process | BP:0006915,apoptosis; BP:0007049,cell cycle; BP:0006915,apoptotic cell death; BP:0016049,cell growth; BP:0008219,cell death; BP:0040007,growth; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 10585263_3, Previously, we reported that p21 was induced in a p53-independent manner during ceramide-induced apoptosis in human hepatocarcinoma cell lines.
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| Reference | 11350897_1, IFN regulatory factor-1 (IRF-1) regulates the IFN system, inhibits cell growth, and has tumor-suppressor activities. p21 is a universal cyclin-dependent kinase inhibitor, the induction of which depends on both p53 and IRF-1 in mouse embryonic fibroblasts.
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| Reference | 11680578_1, Since p21WAF1/CIP1 (p21) is a universal inhibitor of cyclin-dependent kinases and is regulated transcriptionally by p53, which is activated by DNA stress, its expression reflects DNA stress in chronic hepatitis.
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| Reference | 14715082_5, For p21, increase in mRNA by histidine depletion appeared to be independent of p53 transactivation, and the absolute level of p53 protein was unaffected by this treatment.
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| Reference | 16288208_2, The growth effects of AP2alpha are mediated through p21WAF1/CIP1 and the ability for AP2alpha to coactivate p21 requires p53.
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| Reference | 17191126_6, Moreover, p21 expression was observed in both high and low expression of p53.
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| Reference | 21480327_10, Doxorubicin-induced MYBL2 dissociation from LIN9 led to p21(WAF1) up-regulation in p53(+/+) but not in p53(-/-) cell lines.
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| Reference | 22018604_7, In addition, GCTI increased the expression of cell cycle inhibitory proteins (p21, p27 and p53) and the Bax-to-Bcl-2 ratio to induce apoptosis.
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| Reference | 9049198_11, The present study demonstrates that p21 is regulated by p53-dependent and -independent pathways in the liver, and is influenced by both mitogenic and growth inhibitory stimuli.
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| Reference | 9049198_2, In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbeta), differentiation, and apoptosis.
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| Reference | 9719464_4, This apoptotic cell death with p21 induction was also observed in the Hep 3B cells lacking functional p53 after exposure to C6-ceramide.
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