| Identifier | HPI102876 |
| Interaction | p21 protein <==> p53 |
| Role & State | RS:0000068,activator; RS:0000002,activity; |
| Interaction Type | IT:0000068,transcription; IT:0000316,induce; IT:0000285,process; |
| Biological Process | BP:0006915,apoptosis; BP:0040007,growth; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 10874474_4, The activity of cdk2 was inhibited in response to ceramide during this process. p21 protein and mRNA were remarkably induced, while the protein level of p53, known as a transcriptional activator of p21, was not elevated at the same condition. p21 induction was also observed in the Hep3B cells lacking a functional p53 after exposure to ceramide.
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| Reference | 9439773_2, The p21 protein located downstream of p53 was expressed in cell lines with the wild-type p53 but was not expressed in cell lines with the mutant-type p53.
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| Reference | 9568177_10, These findings demonstrate that positive immunostaining for mutant p53 protein expression is a significant indicator of tumor progression and poor prognosis, confirm that p21 protein expression is induced in a p53-dependent manner, and suggest that Rb protein expression may be regulated to some extent by p21 in HCC.
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| Reference | 9719464_3, In SK-HEP-1 cells, the addition of C6-ceramide resulted in a dose- and time-dependent growth suppression and DNA fragmentation characteristics of apoptosis. p21 protein was induced during that process, while the protein level of p53, known as a transcriptional activator of p21, was not elevated under the same condition.
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