| Identifier | HPI103390 |
| Interaction | p53 <==> AFP |
| Role & State | RS:0000077,regulator; RS:0000078,repressor; RS:0000002,activity; |
| Interaction Type | IT:0000071,induction; IT:0000083,precipitation; IT:0000076,inhibition; IT:0000068,transcription; IT:0000168,inhibit; IT:0000174,repress; IT:0000271,express; IT:0000176,suppress; |
| Biological Process | BP:0032502,development; BP:0031497,chromatin assembly; |
| Biological Function | BF:0010843,promoter activity; |
| Subcelluar Location | SCL:0000785,chromatin; |
| Detection Method | DM:0000019,immunoprecipitation; |
| Reference | 10565259_4, Positive cytokeratin 19 was noted in one case (2.5%); AE1 was detected in 40% of patients; p53 was overexpressed in 20% of patients; and AFP was detected in 45% of patients.
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| Reference | 10842185_5, By utilizing in vitro chromatin assembly of DNA templates prior to transcription analysis, we have demonstrated that HBx functionally disrupts p53-mediated repression of AFP transcription through protein-protein interaction.
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| Reference | 14522900_9, Both ING1 and p53 were able to suppress AFP transcription and cause p21 induction; hSIR2, a negative regulator of the p53 protein, showed the opposite effects on the AFP promoter and, like HDAC1, repressed p21 promoter activity.
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| Reference | 15657445_5, Depletion, by small interfering RNA, of SnoN and/or p53 in hepatoma cells disrupted repression of AFP transcription.
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| Reference | 16042885_0, [Molecular mechanism of HCV NS5A on p53's inhibition of AFP expression in hepatocellular carcinoma cells].
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| Reference | 16203738_3, Transient co-transfection of p53 family members showed that p53 and transactivating (TA)-p73, but not TA-p63, repress endogenous AFP transcription additively or independently. p53-independent functions of p73 are further supported by delayed, p73-associated compensation of AFP repression during development of the p53-null mouse.
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| Reference | 18212064_1, In hepatic cells, Smad and SnoN proteins converge with p53 to repress transcription of AFP, an oncodevelopmental tumor marker aberrantly reactivated in hepatoma cells.
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| Reference | 18212064_4, Sequential chromatin immunoprecipitation analyses and molecular modeling indicate that p53 and Smad proteins simultaneously occupy overlapping p53 and Smad regulatory elements to establish repression of AFP transcription.
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| Reference | 9891062_3, HNF-3 protein activates while p53 represses AFP transcription through sequence-specific binding within the previously identified AFP developmental repressor domain.
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| Reference | 9891062_7, Induction of p53 in response to actinomycin D or hypoxic stress decreases AFP expression.
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