| Identifier | HPI103399 |
| Interaction | p53 <==> Akt |
| Role & State | --- |
| Interaction Type | IT:0000123,ubiquitination; IT:0000114,activation; IT:0000068,transcription; IT:0000128,phosphorylation; IT:0000157,depend; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 16800815_5, COX-2 expression blocked these events, concomitant with reduced expression of p53 and promotion of Akt phosphorylation, the latter indicating activation of survival pathways.
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| Reference | 18997816_7, Furthermore, p53 ubiquitination by PRL-1 was achieved through two independent pathways, by inducing PIRH2 transcription and by inducing MDM2 phosphorylation through Akt signaling.
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