| Identifier | HPI103412 |
| Interaction | p53 <==> BclXL |
| Role & State | --- |
| Interaction Type | IT:0000242,direct; IT:0000114,activation; IT:0000026,interact; |
| Biological Process | --- |
| Biological Function | BF:0003677,DNA binding; |
| Subcelluar Location | SCL:0005741,outer mitochondrial membrane; SCL:0000003,membrane; SCL:0000014,mitochondria; |
| Detection Method | --- |
| Reference | 12667443_6, Further, we show that the p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BclXL and Bcl2 proteins, resulting in cytochrome c release. p53 binds to BclXL via its DNA binding domain.
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| Reference | 12667443_7, We probe the significance of mitochondrial p53 and show that tumor-derived transactivation-deficient mutants of p53 concomitantly lose the ability to interact with BclXL and promote cytochrome c release.
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