| Identifier | HPI103413 |
| Interaction | p53 <==> Bid |
| Role & State | --- |
| Interaction Type | IT:0000025,associate; |
| Biological Process | BP:0006915,apoptosis; BP:0008219,cell death; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000006,cytoplasm; SCL:0000008,nucleus; SCL:0000014,mitochondria; |
| Detection Method | --- |
| Reference | 20025574_7, When cells were stimulated by etoposide, p53 could, through the association with Bid, cause translocation of Bid from the nucleus to the cytoplasm and on to its ultimate location in the mitochondria. p53 was physically associated with Bid, and both p53 and Bid cooperatively promoted cell death induced by etoposide.
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| Reference | 20025574_9, These findings reveal a novel mechanism by which p53 is associated with Bid in the nucleus to facilitate exportation of Bid to the mitochondria and induce apoptosis in response to etoposide-induced DNA damage in HCC.
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