| Identifier | HPI103496 |
| Interaction | p53 <==> K-ras mutations |
| Role & State | --- |
| Interaction Type | IT:0000271,express; |
| Biological Process | BP:0016446,mutation; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 11180865_8, Mean interval from the time of diagnosis of PSC until the diagnosis of biliary tract cancer was significantly shorter (P 0.05) in patients with p53 overexpression than in those patients without p53 overexpression (2 versus 47 months). p53 overexpression and K-ras mutations occur commonly in patients with PSC and biliary tract cancer and are associated with a shortened survival. |