| Identifier | HPI103525 |
| Interaction | p53 <==> Notch |
| Role & State | --- |
| Interaction Type | IT:0000092,degradation; IT:0000114,activation; IT:0000078,regulation; IT:0000130,overexpression; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 19376776_5, In this study, we found that overexpression of ICN, the constitutive activated form of Notch1, up-regulated p53 protein expression in HCC cells by inhibiting proteasome degradation. p53 up-regulation was further observed in human primary hepatocellular carcinoma cells after activation of Notch signaling. |