| Identifier | HPI103620 |
| Interaction | p53 <==> hSIR2 |
| Role & State | RS:0000002,activity; |
| Interaction Type | IT:0000059,binding; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 14522900_12, The first is by binding to the AT-motif and excluding HNF1 binding while possibly targeting HAT activity to promoter regions, and the second is by increasing the levels of active, acetylated p53 via binding and inhibiting the ability of hSIR2 to deacetylate p53 protein. |