| Identifier | HPI103747 |
| Interaction | p53 <==> p53R143A |
| Role & State | RS:0000067,receptor; RS:0000002,activity; |
| Interaction Type | --- |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000014,mitochondria; |
| Detection Method | --- |
| Reference | 20233581_3, Mutant forms of p53, namely the hot-spot mutants p53R143A, p53R175D, p53R175H, p53R248W, and p53R273H, acquire anti-apoptotic gain-of-function in hepatocellular carcinoma by repressing the activity of genes regulating both, the extrinsic apoptosis pathway initiated by ligation of death receptors and the intrinsic/mitochondrial apoptosis pathway. |