| Identifier | HPI103750 |
| Interaction | p53 <==> pMdm2 |
| Role & State | RS:0000002,activity; |
| Interaction Type | IT:0000092,degradation; IT:0000128,phosphorylation; |
| Biological Process | --- |
| Biological Function | BF:0016874,ligase activity; |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 17107963_11, Ser-166 phosphorylation of Mdm2 has been shown to increase its ubiquitin ligase activity and increase p53 degradation, and our data indicated an attenuated p53 response to DNA damage in hepatocytes exhibiting high levels of pMdm2 Ser-166.
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