| Identifier | HPI103756 |
| Interaction | p53 <==> pifithrin-alpha |
| Role & State | RS:0000074,inhibitor; RS:0000002,activity; |
| Interaction Type | IT:0000227,bind; IT:0000076,inhibition; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 16882692_8, Conversely, CK2 inhibition had no effect in p53-null cells indicating that the inhibitory effect of CK2 inhibitors requires the presence of p53. p53 activity was not required because overexpression of a p53 mutated in its DNA-binding domain exerted the same effect as wild-type p53 and because the effect of CK2 inhibitors was still observed when p53 activity was inhibited by pifithrin-alpha.
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