| Identifier | HPI103814 |
| Interaction | p53 <==> ribosomal proteins |
| Role & State | --- |
| Interaction Type | IT:0000092,degradation; IT:0000085,synthesis; IT:0000078,regulation; IT:0000114,activation; |
| Biological Process | BP:0032774,RNA synthesis; BP:0006412,protein synthesis; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000016,ribosome; |
| Detection Method | --- |
| Reference | 21399665_4, We found that a downregulation of rRNA synthesis, induced by silencing the POLR1A gene coding for the RNA polymerase I catalytic subunit, stabilised p53 without altering the nucleolar integrity in human cancer cells. p53 stabilisation was due to the inactivation of the MDM2-mediated p53 degradation by the binding of ribosomal proteins no longer used for ribosome building. p53 stabilisation did not occur when rRNA synthesis downregulation was associated with a contemporary reduction of protein synthesis.
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