| Identifier | HPI103827 |
| Interaction | p53 <==> statins |
| Role & State | --- |
| Interaction Type | IT:0000191,decrease; IT:0000092,degradation; IT:0000099,formation; IT:0000225,treat; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 15625077_10, Furthermore, in the DNA-damaged cells, half-lives of Mdm2 and p53 were decreased by statins, indicating a more rapid formation of p53/Mdm2 complexes and facilitated p53 degradation.
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| Reference | 17121917_5, In p53 wild-type cells (HepG2 and A549), pretreatment with statins did not sensitize cells to etoposide in concentrations which induced p53 stabilization.
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