| Identifier | HPI103832 |
| Interaction | p53 <==> tissue growth factor |
| Role & State | --- |
| Interaction Type | IT:0000092,degradation; IT:0000085,synthesis; IT:0000233,connect; |
| Biological Process | BP:0040007,growth; BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | SCL:0005818,aster; |
| Detection Method | --- |
| Reference | 21747166_4, Hepatocyte-specific deletion in mice of the gene encoding Mdm2, a protein that promotes p53 degradation, led to hepatocyte synthesis of connective tissue growth factor (CTGF; the hepatic fibrogenic master switch), increased hepatocyte apoptosis, and spontaneous liver fibrosis; concurrent removal of p53 completely abolished this phenotype.
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