| Identifier | HPI110282 |
| Interaction | stathmin <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000130,overexpression; IT:0000078,regulation; IT:0000077,regulate; |
| Biological Process | BP:0016446,mutation; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 17663418_7, However, stathmin was down-regulated after siRNA-based reduction of p53(mut/Y220C) and p53(mut/R213Q) expression in different tumor cell types.
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| Reference | 17663418_8, CONCLUSION: Our results demonstrate that overexpression of stathmin is an early protumorigenic event in human hepatocarcinogenesis, and its up-regulation can be mediated by gain-of-function mutations in p53.
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