| Identifier | HPI113012 |
| Interaction | wild-type p53 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000266,disruption; |
| Biological Process | BP:0006096,glycolysis; |
| Biological Function | BF:0003677,DNA binding; |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 12857899_4, Moreover, in p53-deficient liver cell lines, only reconstitution with wild-type p53, but not mutated p53 lacking DNA binding capacity, showed this effect.
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| Reference | 16728594_6, Disruption of the SCO2 gene in human cancer cells with wild-type p53 recapitulated the metabolic switch toward glycolysis that is exhibited by p53-deficient cells.
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| Reference | 9380755_4, To test the hypothesis that wild-type p53 regulates the endogenous mdr1 gene we stably introduced a trans-dominant negative (TDN) p53 into rodent H35 hepatoma cells that express P-glycoprotein (Pgp) and have wild-type p53.
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