| Identifier | MPI12934 |
| Interaction | HBx <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000200,repair; IT:0000068,transcription; |
| Biological Process | BP:0040007,growth; BP:0006281,DNA repair; BP:0016049,growth of cell; BP:0016446,mutation; BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 8903370_13, These data show that HBx has a weak tumorigenicity in murine hepatocytes and that the addition of mutation of p53 at codon 249 to HBx expression does not increase tumorigenicity in AML12 cells.
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| Reference | 9837906_6, We demonstrate that HBx expression affects DNA repair in a p53-dependent manner.
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| Reference | 10490818_5, We report that HBx inhibits clonal outgrowth of cells and induces apoptosis by a p53-independent pathway.
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| Reference | 11278765_3, Herein we report that HBx represses two components of the transcription-repair factor TFIIH, XPB (p89), and XPD (p80), both in p53-proficient and p53-deficient liver cells.
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| Reference | 11821950_2, Using a transgenic mouse model, we have recently shown that HBx stimulates the apoptotic turnover of hepatocytes, independently of p53.
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| Reference | 15681062_6, To evaluate the importance of the cysteine residues in HBx for its interaction with RNA and p53 we expressed full-length HBx-wt as well as several truncated mini-HBx(18-142) proteins with multiple cysteine to serine point mutations as 6xHis fusion proteins in Escherichia coli.
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| Reference | 16937438_3, We have studied whether HBx may have different effects on p53 depending on the cell type.
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