| Identifier | MPI47647 |
| Interaction | p53 <==> NOS2 |
| Role & State | --- |
| Interaction Type | --- |
| Biological Process | BP:0010467,gene expression; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 8637893_5, These data are consistent with the hypothesis of a negative feedback loop in which endogenous NO-induced DNA damage results in WT p53 accumulation and provides a novel mechanism by which p53 safeguards against DNA damage through p53-mediated transrepression of NOS2 gene expression, thus reducing the potential for NO-induced DNA damage. |