Identifier | HPI068711 |
Interaction | STAT3/5 <==> p53 |
Role & State | RS:0000068,activator; |
Interaction Type | IT:0000068,transcription; IT:0000078,regulation; |
Biological Process | --- |
Biological Function | --- |
Subcelluar Location | --- |
Detection Method | --- |
Reference | 15604280_3, Whereas irinotecan-induced up-regulation of the proapoptotic proteins PUMA and Noxa requires p53, we find that irinotecan inhibits Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 and 5 (STAT3/5) signaling in both p53-proficient and p53-deficient tumor cells. |