| Identifier | HPI072310 |
| Interaction | TGF-beta1 <==> p53 |
| Role & State | RS:0000014,deacetylation; |
| Interaction Type | IT:0000364,acetylation; IT:0000139,dephosphorylation; IT:0000128,phosphorylation; IT:0000114,activation; IT:0000132,methylation; IT:0000316,induce; IT:0000294,stimulate; IT:0000275,mediate; |
| Biological Process | BP:0040007,growth; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000010,cytosol; |
| Detection Method | --- |
| Reference | 11799106_10, In contrast, TGF-beta1-mediated promotion of fibroblast growth failed to mediate p53 x IkappaBalpha dissociation.
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| Reference | 15004518_9, In conclusion, the results demonstrated that TGF-beta1-induced p53 dephosphorylation is associated with caspase-3 activation, and cytosolic translocation of p21(Cip1/Waf1) and p27(Kip1), resulting in decreased expression of Cdks and cyclins.
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| Reference | 15657445_4, ChIP assays show that TGF-beta1 stimulates p53, Smad4, P-Smad2 binding, and histone H3K9 deacetylation and methylation, at the SBE/p53RE.
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