| Identifier | HPI072664 |
| Interaction | TIP30 <==> p53 |
| Role & State | RS:0000002,activity; |
| Interaction Type | IT:0000316,induce; IT:0000193,enhance; IT:0000068,transcription; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | BF:0016563,transcriptional activity; |
| Subcelluar Location | SCL:0000014,mitochondria; |
| Detection Method | --- |
| Reference | 16799960_6, Ectopic expression of TIP30 in HCC cells enhanced p53 expression and decreased Bcl-2/Bcl-xL expression.
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| Reference | 18519672_6, TIP30 greatly enhanced p53 expression and its transcriptional activity under oxidative stress, which was probably through stabilization of p53 mRNA.
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| Reference | 18519672_7, TIP30 induced apoptosis and mitochondrial dysfunction were blocked by silencing of p53 expression.
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