| Identifier | HPI073696 |
| Interaction | TNP-470 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000114,activation; IT:0000076,inhibition; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 17196522_10, In conclusion, cell-cycle inhibition by TNP-470 is mediated at least in part by an activation of p21WAF1/CIP1 because of a p53-dependent mechanism, with reduction of the cyclin D-Cdk4 and cyclin E-Cdk 2 expression. |