Identifier | HPI078098 |
Interaction | X protein <==> p53 |
Role & State | RS:0000080,suppressor; |
Interaction Type | IT:0000004,co-expression; IT:0000068,transcription; IT:0000026,interact; IT:0000114,activation; |
Biological Process | --- |
Biological Function | --- |
Subcelluar Location | SCL:0000008,nucleus; |
Detection Method | --- |
Reference | 7559743_6, This p53 repression on the X gene promoter was cancelled by X gene co-expression, probably indicating that the X protein disrupts the p53 tumor suppressor function in the nucleus.
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Reference | 7559743_7, All data suggest that X protein leads to transactivation of cellular oncogenes by preventing an interaction between p53 and cellular transcription factor(s) consisting of the basal transcriptional machinery.
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