Identifier | HPI084381 |
Interaction | bcl-2 <==> p53 |
Role & State | --- |
Interaction Type | IT:0000078,regulation; IT:0000176,suppress; |
Biological Process | BP:0006915,apoptosis; BP:0007049,cell cycle; BP:0051320,S phase; |
Biological Function | --- |
Subcelluar Location | --- |
Detection Method | --- |
Reference | 10091108_2, It is under genetic control, bcl-2 being the major apoptosis suppressing gene, while p53 and c-myc are apoptosis promoting genes.
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Reference | 16458489_8, These results demonstrate that oxymatrine inhibit the proliferation and induce apoptosis of human hepatoma SMMC-7721 cells, and suggest that this effect was mediated probably by a significant cell cycle blockage in G2/M and S phase, down-regulation of bcl-2 and up-regulation of p53.
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