Identifier | HPI102599 |
Interaction | p14 <==> p53 |
Role & State | RS:0000002,activity; RS:0000080,suppressor; |
Interaction Type | IT:0000364,acetylation; IT:0000227,bind; |
Biological Process | BP:0016049,cell growth; BP:0040007,growth; |
Biological Function | --- |
Subcelluar Location | SCL:0005694,chromosome; |
Detection Method | --- |
Reference | 11982701_1, Chromosome 9p21, a locus comprising the tumor suppressor genes (TSG) p16(INK4a) and p14(ARF), is a common region of loss of heterozygosity (LOH) in hepatocellular carcinoma (HCC). p14(ARF) shares exon 2 with p16 in a different reading frame. p14 binds to MDM2 resulting in a stabilization of functional p53.
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Reference | 11982701_2, This study examined the roles of p14, p16 and p53 in hepatocarcinogenesis, in 37 Australian and 24 South African patients.
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Reference | 19085961_9, CONCLUSION: ING1 variants p33(ING1b) and p24(ING1c) may modulate p53 activity and subsequently inhibit hepatoma cell growth by at least two possible mechanisms: interacting with Mdm2 and p14(arf) to stabilize and activate p53, or increasing p53 acetylation.
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