| Identifier | HPI102762 |
| Interaction | p21 (WAF1) promoter <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000114,activation; IT:0000068,transcription; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 12379483_9, Furthermore, NS5A repressed the p53 regulated p21 (WAF1) promoter and a synthetic promoter containing multiple p53 responsive DNA elements binding sites in HCT116 p53(+/+) cell line. p53-mediated transcriptional activation from both promoters was reduced approximately 3-5-fold following expression of NS5A. |