| Identifier | HPI102765 |
| Interaction | p21 (WAF1/CIP1 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000078,regulation; IT:0000271,express; |
| Biological Process | BP:0016032,viral infection; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 10883667_5, These results suggest that: (1) different modes of p21(WAF1/CIP1) regulation are involved in HCCs differing in their hepatitis viral infection status, and p21(WAF1/CIP1) expression appears to be predominantly related to altered p53 in HCV-related HCCs; (2) disruption of the p53-p21(WAF1/CIP1) cell-cycle-regulating pathway may contribute to malignant progression of HCC.
|
| Reference | 11870547_2, To investigate the role of p21(WAF1/CIP1) in proliferation of human liver cancer cells, we examined the expression of p53, p21(WAF1/CIP1), cdk2 and cdk4 expression in two human liver cancer cell lines (HepG2 and PLC/PRF/5 cells).
|
| |
|