Detail information of PPI "HPI102777"

IdentifierHPI102777
Interactionp21 (WAF1/CIP1) protein  <==>  p53
Role & State        ---
Interaction TypeIT:0000271,express;
Biological Process        ---
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference10883667_0, Reduced p21(WAF1/CIP1) protein expression is predominantly related to altered p53 in hepatocellular carcinomas.
Reference10883667_1, To investigate the relationship between the expression of p21(WAF1/CIP1) protein and p53 status and the possible role of the two proteins in hepatocellular carcinomas (HCCs), we examined the expression of p21(WAF1/CIP1) and p53 immunohistochemically in 81 tumours from 65 patients with hepatocellular carcinoma. p21(WAF1/CIP1) protein was absent from 59 of 81 tumours (72.8%), and altered p53 expression was found in 43 (53.1%). p21(WAF1/CIP1) expression was significantly associated with p53 status (P = 0.0008); 38 of 59 tumours lacking p21(WAF1/CIP1) protein were accompanied by altered p53 expression.