Detail information of PPI "HPI103231"

IdentifierHPI103231
Interactionp38  <==>  p53
Role & StateRS:0000074,inhibitor;
Interaction TypeIT:0000114,activation; IT:0000128,phosphorylation; IT:0000206,promote;
Biological Process        ---
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference18719315_2, Moreover, the ROS activated the p38 kinase, which in turn promoted the activation of p53, as verified by evidence showing that the ROS scavenger N-acetyl-cysteine (NAC) not only blocked the phosphorylation of p38 but also partially inhibited the activation of p53, and the p38 inhibitor SB203580 reduced the activation of p53 as well.