Identifier | HPI103231 |
Interaction | p38 <==> p53 |
Role & State | RS:0000074,inhibitor; |
Interaction Type | IT:0000114,activation; IT:0000128,phosphorylation; IT:0000206,promote; |
Biological Process | --- |
Biological Function | --- |
Subcelluar Location | --- |
Detection Method | --- |
Reference | 18719315_2, Moreover, the ROS activated the p38 kinase, which in turn promoted the activation of p53, as verified by evidence showing that the ROS scavenger N-acetyl-cysteine (NAC) not only blocked the phosphorylation of p38 but also partially inhibited the activation of p53, and the p38 inhibitor SB203580 reduced the activation of p53 as well. |