Identifier | HPI103388 |
Interaction | p53 <==> 2 -chloroethyl-3 -sarcosinamide-1 -nitrosourea |
Role & State | --- |
Interaction Type | IT:0000078,regulation; IT:0000128,phosphorylation; |
Biological Process | --- |
Biological Function | --- |
Subcelluar Location | --- |
Detection Method | --- |
Reference | 15754328_3, In the present study, we report that in vitro treatment of primary hepatoma, HepG2 (wild-type p53), PLC/PRF/5 (p53-mutant), and Hep3B (p53-deleted) cells with 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU) resulted in upregulation of p53, p21(Cip1/Waf1), phosphorylated cdc-2 at Tyr15 in wild-type p53 cells and phosphorylation of cdc-2 at Tyr15 in p53-mutant or p53-deleted hepatoma cells. |