| Identifier | HPI103464 |
| Interaction | p53 <==> HBxAg |
| Role & State | RS:0000080,suppressor; |
| Interaction Type | IT:0000114,activation; IT:0000059,binding; IT:0000050,disrupt; |
| Biological Process | BP:0007050,cell cycle arrest; BP:0006915,apoptosis; BP:0051726,cell cycle control; BP:0007049,cell cycle; BP:0006917,induction of apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 9931385_3, Recent work has now defined one of these steps as the physical binding and functional inactivation of the tumor suppressor protein, p53, by HBxAg.
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| Reference | 9931385_4, The centrality of p53 to genomic stability, cell cycle arrest, induction of apoptosis, and in senescence related pathways, suggests that its disruption by HBxAg will result in genomic instability, loss of cell cycle control, a lower apoptotic rate, and an extension in the life span of HBV-infected cells.
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