Detail information of PPI "HPI103473"

IdentifierHPI103473
Interactionp53  <==>  HNF6 alpha
Role & StateRS:0000077,regulator; RS:0000002,activity;
Interaction TypeIT:0000076,inhibition; IT:0000078,regulation;
Biological Process        ---
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference16895524_9, The down-regulation was partially recovered by inhibition of HDAC activity and appears to involve the positive regulator HNF6alpha. p53 bound HNF6alpha in vivo and in vitro and prevented HNF6alpha from binding DNA in vitro. p53 also repressed stimulation of the P1 promoter by HNF6alpha in vivo.