| Identifier | HPI103487 |
| Interaction | p53 <==> IGF-IR antibody |
| Role & State | RS:0000067,receptor; |
| Interaction Type | IT:0000258,prevent; |
| Biological Process | BP:0016446,mutation; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000002,intracellular; |
| Detection Method | --- |
| Reference | 12782403_1, The aim of the present study was to investigate the intracellular mediators of the third base mutant of codon 249 in p53 gene (p53mt249) mutation that potentiate IGF-II dependent IGF-I receptor (IGF-IR) signaling. p53mt249 enhanced IGF-II dependent IGF-IR signaling in p53 negative Hep3B hepatoma cells which were specifically prevented by IGF-IR antibody, alpha IR3 and lovastin. p53mt249 increased the number of IGF-II binding sites with no change in the affinity of IGF-IR. |