Identifier | HPI103488 |
Interaction | p53 <==> IGFBP1 |
Role & State | --- |
Interaction Type | IT:0000114,activation; IT:0000068,transcription; IT:0000271,express; IT:0000227,bind; IT:0000099,formation; |
Biological Process | BP:0040007,growth; BP:0008219,cell death; |
Biological Function | --- |
Subcelluar Location | --- |
Detection Method | --- |
Reference | 18056423_2, Here we show that p53 transcriptional activation leads to enhanced expression of hepatic IGFBP1 (insulin-like growth factor-binding protein-1).
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Reference | 18285608_4, It appears that p53-mediated induction of the gene that encodes insulin-like growth factor-binding protein-1 (IGFBP1) attenuates the cell death response in hepatocytes by preventing the formation of a complex between p53 and the proapoptotic protein BAK.
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