| Identifier | HPI019707 |
| Interaction | Cyr61 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000078,regulation; IT:0000316,induce; |
| Biological Process | BP:0000279,M phase; BP:0016049,cell growth; BP:0040007,growth; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 17698398_8, Furthermore, upon exposure to 5-Fluorouracil and UV irradiation, Cyr61 was rapidly induced in both p53(+/+) HepG2 and p53(-/-) Hep3B cells.
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| Reference | 17698398_9, However, only HepG2 cells showed increased G2/M phase arrest with concomitant up-regulation in p53 and p21 levels, suggesting that Cyr61 may play an active role in regulating HCC cell growth involving p53 as well as alternative pathways.
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