| Identifier | HPI103519 |
| Interaction | p53 <==> NOS2 |
| Role & State | RS:0000077,regulator; RS:0000078,repressor; |
| Interaction Type | IT:0000174,repress; IT:0000064,production; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 9671763_10, Although NO production and NOS2 protein expression were increased similarly in KO and wt p53 mice 10 days after injection of C. parvum, NOS2 expression returned to baseline levels only in wt p53 controls while remaining up-regulated in p53 KO mice.
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| Reference | 9671763_11, These genetic and functional data indicate that p53 is an important transrepressor of NOS2 expression in vivo and attenuates excessive NO production in a regulatory negative feedback loop.
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