| Identifier | HPI103543 |
| Interaction | p53 <==> ROS |
| Role & State | RS:0000074,inhibitor; RS:0000080,suppressor; |
| Interaction Type | IT:0000238,link; |
| Biological Process | BP:0006915,apoptosis; BP:0008152,metabolism; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 18719315_1, Oridonin, a diterpenoid isolated from Rabdosia rubescences, could induce apoptosis through the generation of reactive oxygen species (ROS) in human hepatoma HepG2 cells. p53, a specific inhibitor of pifithrin alpha (PFT alpha), markedly inhibited ROS generation and apoptosis, showing that p53 was responsible for the cytotoxity of oridonin through mediation by ROS.
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| Reference | 20351271_9, Thus, our results provide evidence for a unique metabolic role for p53, linking glutamine metabolism, energy, and ROS homeostasis, which may contribute to p53 tumor suppressor function.
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