Identifier | HPI103557 |
Interaction | p53 <==> TLR3 |
Role & State | RS:0000067,receptor; RS:0000080,suppressor; |
Interaction Type | IT:0000077,regulate; IT:0000068,transcription; |
Biological Process | BP:0006955,immune response; BP:0045087,innate immune response; |
Biological Function | --- |
Subcelluar Location | --- |
Detection Method | --- |
Reference | 18779317_10, These results suggest that p53 influences TLR3 expression and function and highlight a role of p53 in innate immune response in epithelial cells.
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Reference | 18779317_3, Here we show that the tumor suppressor p53 positively regulates the transcription of TLR3, a receptor for viral double-stranded RNA and poly(I-C), by binding to the p53 site in the TLR3 promoter.
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