| Identifier | HPI103569 |
| Interaction | p53 <==> VEGF |
| Role & State | RS:0000002,activity; |
| Interaction Type | IT:0000130,overexpression; IT:0000032,increase; IT:0000080,effect; IT:0000068,transcription; |
| Biological Process | BP:0016446,mutation; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 12118317_4, Therefore, this in vivo study was performed to assess p53 mutations, i.e. hot spots in exons 4-9, in primary colorectal cancers and in corresponding liver metastases in order to test whether there is an association between p53 mutated tumours with increased microvessel density (MVD) and VEGF overexpression.
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| Reference | 12808060_9, However, no significant correlation was found between overexpression of p53 and the expression of VEGF, angiopoietins, or MVD.
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| Reference | 9377555_2, Based on its effects when overexpressed in transient transfection assays, p53 has been proposed to repress VEGF transcription.
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| Reference | 9377555_5, Our data provide no evidence for a causal relationship between the loss of p53 activity and increased VEGF expression that is observed during tumor progression.
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| Reference | 9703827_3, There were significant differences between patients positive for p53 and patients negative for p53, between patients positive for VEGF and patients negative for VEGF, with respect to the occurrence of liver metastases.
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| Reference | 9703827_5, The frequency of patients positive for both p53 and v, both VEGF and v in the liver metastases group, was significantly higher than in the control group.
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