| Identifier | HPI103585 |
| Interaction | p53 <==> antiapoptotic proteins |
| Role & State | RS:0000002,activity; RS:0000080,suppressor; |
| Interaction Type | IT:0000078,regulation; IT:0000068,transcription; IT:0000238,link; |
| Biological Process | BP:0051726,cell cycle control; BP:0007049,cell cycle; BP:0008219,cell death; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 10969820_1, Loss of function of the tumor suppressor protein p53 represents a very frequent event in human carcinogenesis, but the molecular mechanisms linking impaired p53 activity to increased cell malignancy are still incompletely understood. p53 is normally involved in both cell cycle control and the induction of cell death and is involved in the latter mainly through the transcriptional regulation of pro- and antiapoptotic proteins.
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