| Identifier | HPI103605 |
| Interaction | p53 <==> cyclin D1 |
| Role & State | RS:0000074,inhibitor; |
| Interaction Type | IT:0000078,regulation; IT:0000271,express; IT:0000114,activation; |
| Biological Process | BP:0040007,growth; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 10385644_4, Aberrant p53 expression and cyclin D1 and E overexpression were observed exclusively in HCC lesions. pRb was positive in 85.6% of the HCC cases and was not related to any clinicopathological parameters.
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| Reference | 12223131_0, [Chronobiologic contrast of expression of p53, p16, and cyclin D1 in hepatocarcinoma cells].
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| Reference | 12378511_0, Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4/Dpc4 in intrahepatic cholangiocarcinoma.
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| Reference | 15517885_4, The growth-inhibitory effects of resveratrol are mediated through cell-cycle arrest; upregulation of p21Cip1/WAF1, p53 and Bax; down-regulation of survivin, cyclin D1, cyclin E, Bcl-2, Bcl-xL and clAPs; and activation of caspases.
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| Reference | 16940298_7, Down-regulation of the HBx protein level by p53 also reduced HBx-mediated cyclin D1 up-regulation.
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