| Identifier | HPI103706 |
| Interaction | p53 <==> p21 (CIP1/WAF1) |
| Role & State | --- |
| Interaction Type | IT:0000076,inhibition; IT:0000078,regulation; |
| Biological Process | BP:0040007,growth; BP:0016246,RNA interference; BP:0051320,S-phase; BP:0007049,cell cycle; BP:0007050,cell cycle arrest; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | DM:0000256,rna interference; |
| Reference | 22226916_10, Ku80 overexpression caused S-phase cell cycle arrest and was associated with upregulation of p53 and p21(CIP1/WAF1), and the inhibition of p53 or p21(CIP1/WAF1) expression by RNA interference overcame the growth suppression and S-phase arrest in the Ku80-expressing cells.
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