| Identifier | HPI103708 |
| Interaction | p53 <==> p21 (Cip1/Waf1) |
| Role & State | --- |
| Interaction Type | IT:0000076,inhibition; IT:0000139,dephosphorylation; IT:0000128,phosphorylation; IT:0000114,activation; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000006,cytoplasm; SCL:0000010,cytosol; |
| Detection Method | --- |
| Reference | 15004518_7, In addition, p53 dephosphorylation coincided with caspase-3 activation, and translocation of p21(Cip1/Waf1) and p27(Kip1) into the cytoplasm, all of which were suppressed by caspase inhibition of TGF-beta1-induced apoptosis.
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| Reference | 15004518_9, In conclusion, the results demonstrated that TGF-beta1-induced p53 dephosphorylation is associated with caspase-3 activation, and cytosolic translocation of p21(Cip1/Waf1) and p27(Kip1), resulting in decreased expression of Cdks and cyclins.
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