| Identifier | HPI103735 |
| Interaction | p53 <==> p53 mutations |
| Role & State | --- |
| Interaction Type | IT:0000271,express; IT:0000132,methylation; IT:0000153,consist; |
| Biological Process | BP:0016446,mutation; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 12845670_7, Alterations of the p53 pathway consisted mostly of p53 mutations or p14(ARF) promoter methylation (20-48%).
|
| Reference | 15500550_1, To determine the relationship between p53 altered expression and p53 mutations in hepatocellular carcinoma (HCC), we analysed p53 protein immunohistochemically and assessed the presence of mutations in exons 4-8 of the p53 gene using SSCP assay in 117 HCCs corresponding to 78 patients.
|
| Reference | 15548361_2, To clarify this phenomenon for colorectal cancer and to find out if this preferential loss might have any functional significance, p53 loss of heterozygosity (LOH) and p53 mutations were investigated in a group of 61 colorectal cancers and 28 liver metastases, and were correlated with clinicopathologic factors.
|
| |
|