| Identifier | HPI103695 |
| Interaction | p53 mutations <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000099,formation; IT:0000114,activation; |
| Biological Process | BP:0032502,development; BP:0016446,mutation; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000002,intracellular; |
| Detection Method | --- |
| Reference | 10767646_1, p53 mutations and binding of p53 to hepatitis B virus (HBV) x protein (HBx) have been suggested as alternative mechanisms of development of hepatocellular carcinomas (HCCs) in man, both processes resulting in intracellular accumulation of the protein which is detectable by immunohistochemical approaches.
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| Reference | 12141446_2, Post-natally, p53 mutations are associated with many cancers and mice lacking p53 are prone to spontaneous tumour formation.
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| Reference | 9012469_9, The low frequency of p53 mutations in HCC in these patients implies that p53 inactivation may occur predominantly by complex formation with HBxAg.
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