| Identifier | HPI103797 |
| Interaction | p53 protein <==> p53 |
| Role & State | RS:0000080,suppressor; |
| Interaction Type | IT:0000128,phosphorylation; IT:0000071,induction; IT:0000068,transcription; |
| Biological Process | BP:0006917,induction of apoptosis; BP:0006915,apoptosis; BP:0016446,mutation; |
| Biological Function | BF:0003677,DNA binding; |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 10420846_2, Many cells respond to DNA damage by the induction of apoptosis, which depends on a functional p53 protein and is signaled by elevation of p53 levels.
|
| Reference | 10499623_4, We hypothesized that the complete absence of intact p53 protein as seen with p53 null mutations may be associated with an enhanced tendency to develop distant metastatic disease.
|
| Reference | 15259070_0, HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding.
|
| Reference | 17029827_6, The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced.
|
| Reference | 17373730_6, High expression of p53 in vivo may exert therapeutic effects on HCC in two aspects: (1) High expression of exogenous p53 protein induces apoptosis of tumor cells by inhibiting proliferation of cells through several biologic pathways and (2) Exogenous p53 renders HCC more sensitive to some chemotherapeutic agents.
|
| Reference | 18294283_4, We found that six phosphorylation sites of the Serine residues of p53 were efficiently phosphorylated in HBx-expressing ChangX-34 cells, suggesting that the binding of HBx to the p53 protein does not interfere with the phosphorylation of p53 by signaling kinases.
|
| Reference | 21411755_1, The p53 protein is a pivotal tumor suppressor that is frequently mutated in many human cancers, although precisely how p53 prevents tumors is still unclear.
|
| Reference | 21438026_4, Both WtHBx and MutHBx proteins physically interact with p53 protein, but have different impacts on p53-mediated gene transcription.
|
| Reference | 9430645_4, The p53 protein binds to a defined region within the HBV enhancer in a sequence-specific manner, and this, surprisingly, results in p53-dependent transcriptional repression in the context of the whole HBV enhancer.
|
| |
|